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Viagra (sildenafil) tends to get all the attention. After all, it was the first FDA-approved oral erectile dysfunction (ED) medication, and it became a household name soon after. But its close cousin, Cialis (tadalafil), is also an effective option for many men who experience ED. Cialis is a longer-acting option that some men prefer over other ED treatments.

Here, we’ll tell you everything you need to know about Cialis, including how it works, how long it lasts, and potential side effects. We’ll also provide tips on how to use it safely.

What is Cialis, and how does it work to treat erectile dysfunction?

ED happens when there is not enough blood flow to the penis. This can be a result of a medical problem, medications, or emotional problems. Your healthcare provider can help determine the cause and whether medication might be right for you.

Good to know: Cialis only works if you’re sexually aroused. If you’re not aroused, you likely won’t be able to get an erection.

How quickly does Cialis work?

Cialis works relatively quickly. You may start to feel its effects after about 30 minutes. But it can take up to 2 hours for its full effects to kick in.

By comparison, Viagra begins to work within 30 minutes; its maximum effects generally appear after 45 minutes to 1 hour. Other similar ED medications can start working even faster. Vardenafil can start working in about 15 minutes and avanafil (Stendra) has a start time of under 15 minutes. Their maximum effects also tend to appear in under an hour.

Studies show Cialis is absorbed quickly, and it’s not affected by the timing of meals. In other words, you can take Cialis with or without food — it won’t affect how fast it works.

How long does Cialis last?

The effects of Cialis last noticeably longer than the effects of Viagra — normally up to 36 hours. That’s a full 1.5 days. Viagra usually lasts for up to 5 hours.

Don’t be alarmed, though. That doesn’t mean you’ll have an erection for more than a day straight. That would be a medical emergency. But you may be able to achieve an erection with the help of Cialis throughout the 36-hour time period. This is one of the reasons some men prefer Cialis: It allows for more spontaneous sexual activity.

If your erection lasts longer than 4 hours, even if it’s not painful, consider it a medical emergency. Known as priapism, this condition can cause permanent damage if it’s left untreated.

How should I take Cialis?

Many people can benefit from Cialis. But knowing how to get the maximum effect from Cialis can enhance your experience with it. Here are a few tips for taking Cialis safely and effectively.

1. Follow safe, recommended Cialis doses

If you’d like to take Cialis for ED, you’ve got two options. You can take one of the higher-dose tablets on an as-needed basis (when you want to have sex), or you can take a smaller-dose tablet every day.

A 10 mg tablet is usually recommended for as-needed use, though some men might find that a lower (5 mg) or higher (20 mg) dose works better for them. The 2.5 mg and 5 mg tablets are more common choices for daily, scheduled doses.

According to several studies, there’s no difference in safety or effectiveness between these two Cialis dosage options.

2. You can’t generally make Cialis work faster

If you take Cialis as needed, be sure to give yourself plenty of time (since it takes up to 2 hours to kick in). You can’t speed it up after you’ve taken it.

If that’s not working for you, you could consider taking a lower-dose tablet every day. This might be better if you prefer to be more spontaneous. If so, be sure to take it at the same time every day.

No matter which way you decide to take it, don’t take more than one dose per day. This helps prevent unnecessary risks and additional side effects.

3. Watch out for interactions with other medications

ED medications combined with medications for high blood pressure can cause dangerously low blood pressure. Never take Cialis if you take nitroglycerin or another nitrate medication for chest pain or high blood pressure. These medications can worsen the risk of dangerously low blood pressure:

• Nitroglycerin (Nitrostat)

• Isosorbide mono (Monoket)

• Isosorbide dinitrate (Isordil)

Other medications or foods can also cause Cialis interactions. They may lead to additional side effects. Keep these substances in mind:

• Alpha blockers like terazosin, tamsulosin (Flomax), and doxazosin (Cardura)

• Oral antifungal medications like ketoconazole

• Antibiotics like erythromycin (Ery-Tab)

• Riociguat (Adempas)

• Blood pressure medications

• Other PDE5 inhibitors

• Grapefruit

• Alcohol